Metabolic regulation of human immune responses

Research Area

  • Macrophage- and T-helper-cell-mediated host defense in humans
  • The role of immunometabolism in infectious and non-infectious skin diseases

Research Projects

Our lab studies molecular mechanisms that regulate human immune responses in skin. We are particularly interested in the molecular cross talk between metabolic pathways and immune signaling in macrophages and T helper cells. While during the past years, we have focused on the interaction of steroid hormones, vitamin D and glucocorticoids, and immune signaling, we are now analyzing additional immunometabolic pathways. Current projects concentrate on the role of vitamin D and iron metabolisms in the macrophage host response and the role of core metabolic pathways in driving macrophage and Th cell responses in infectious and non-infectious skin inflammation. We believe that increased knowledge of the immune-metabolic pathways involved in human skin diseases carries excellent potential for future clinical translation.

Group Members

Selected Publications

Bopp L, Martinez ML, Schumacher C, Seitz R, Arana MH, Klapproth H, Lukas D, Oh JH, Neumayer D, Lackmann JW, Mueller S, von Stebut E, Brachvogel B, Brodesser S, Klein Geltink RI, Fabri M. Glutamine promotes human CD8+ T cells and counteracts imiquimod-induced T cell hyporesponsiveness. iScience. 2024 Apr 18;27(5):109767. 

Baixauli F, Piletic K, Puelston DJ, Villa M, Field CS, Flachsmann L, Quintana A, Rana N, Edwards-Hicks J, Matsushita M, Stanczak M, Grzes KM, Kabat AM, Fabri M, Caputa G, Kelly B, Corrado M, Musa Y, Duda KJ, Mittler G, O'Sullivan D, Sesaki H, Jenuwein T, Buescher JM, Pearce EJ, Sanin DE, Pearce EL. An LKB1-mitochondria axis controls Th17 effector function.Nature. 2022 Oct 610(7932):555-561.

Knoke K, Rongisch RR, Grzes KM, Schwarz R, Lorenz B, Yogev N, Pearce EL, Pearce EJ, Kofler DM, Fabri M. Tofacitinib suppresses IL-10/IL-10R signaling and modulates host defense responses in human macrophages. J Invest Dermatol. 2022 Mar;142(3 Pt A):559-570.e6.

Fabri M, Villa M, Stanczak MA, Edwards-Hicks J, Corrado M, Pearce EL. Research Techniques Made Simple: Profiling Cellular Energy Metabolism. J Invest Dermatol. 2021 Dec 141, 2767e2774.

Grzes KM, Sanin DE, Kabat AM, Stanczak MA, Edwards-Hicks J, Matsushita M, Hackl A, Hässler F, Knoke K, Zahalka S, Villa M, Kofler DM, Voll RE, Zigrino P, Fabri M, Pearce EL, Pearce EJ. Plasmacytoid dendritic cell activation is dependent on coordinated expression of distinct amino acid transporters. Immunity. 2021 Nov 9;54(11):2514-2530.e7.

O'Sullivan D, Stanczak MA, Villa M, Uhl FM, Corrado M, Klein Geltink RI, Sanin DE, Apostolova P, Rana N, Edwards-Hicks J, Grzes KM, Kabat AM, Kyle RL, Fabri M, Curtis JD, Buck MD, Patterson AE, Regina A, Field CS, Baixauli F, Puleston DJ, Pearce EJ, Zeiser R, Pearce EL. Fever supports CD8+ effector T cell responses by promoting mitochondrial translation. Proc Natl Acad Sci. 2021 Jun 22;118(25):e2023752118.

Klein Geltink RI, Edwards-Hicks J, Apostolova P, O'Sullivan D, Sanin DE, Patterson AE, Puleston DJ, Ligthart NAM, Buescher JM, Grzes KM, Kabat AM, Stanczak M, Curtis JD, Hässler F, Uhl FM, Fabri M, Zeiser R, Pearce EJ, Pearce EL. Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy. Nat Metab. 2020 Aug;2(8):703-716.

de Castro Kroner J, Knoke K, Kofler DM, Steiger J, Fabri M. Glucocorticoids promote intrinsic human Th17 differentiation. J Allergy Clin Immunol. 2018 Nov;142(5):1669-1673.e11.

Steiger J, Stephan A, Inkeles MS, Realegeno S, Bruns H, Kröll P, de Castro Kroner J, Sommer A, Batinica M, Pitzler L, Kalscheuer R, Hartmann P, Plum G, Stenger S, Pellegrini M, Brachvogel B, Modlin RL, Fabri M. Imatinib Triggers Phagolysosome Acidification and Antimicrobial Activity against Mycobacterium bovis Bacille Calmette-Guérin in Glucocorticoid-Treated Human Macrophages. J Immunol. 2016 Jul 1;197(1):222-32.

Fabri M, Stenger S, Shin DM, Yuk JM, Liu PT, Realegeno S, Lee HM, Krutzik SR, Schenk M, Sieling PA, Teles R, Montoya D, Iyer SS, Bruns H, Lewinsohn DM, Hollis BW, Hewison M, Adams JS, Steinmeyer A, Zügel U, Cheng G, Jo EK, Bloom BR, Modlin RL. Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages. Sci Transl Med. 2011 Oct 12;3(104):104ra102.

Publikationen Univ.-Prof. Dr. Mario Fabri